KLKB1 and MST1

Data Source:
HPRD (in vitro)

		KLKB1	MST1
Description		kallikrein B1	macrophage stimulating 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Factor XII Activation Proteolysis Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis	Proteolysis Regulation Of Macrophage Chemotaxis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H2A-S139 Phosphorylation Negative Regulation Of Gluconeogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema	Signaling by MST1
Drugs		Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases		Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite levels ( 24625756 23093944)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 28067908 23128233) Primary sclerosing cholangitis ( 23603763 27992413 21151127) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 19915572 28067908 20228799 25082827 21297633)
Interacting Genes		8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2	10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2
Entrez ID		3818	4485
HPRD ID		01971	00798
Ensembl ID		ENSG00000164344	ENSG00000173531
Uniprot IDs		A8K9A9 B4DMX2 E9PBC5 P03952	G3XAK1 P26927 Q53GN8
PDB IDs		2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P	2ASU 4QT8
Enriched GO Terms of Interacting Partners?
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