KLKB1 and TFPI2

Data Source:
HPRD (in vitro)

		KLKB1	TFPI2
Description		kallikrein B1	tissue factor pathway inhibitor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Extracellular Space Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent
	Biological Process	Factor XII Activation Proteolysis Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis	Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs		Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases		Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite levels ( 24625756 23093944)	Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042)
Interacting Genes		8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2	5 interacting genes: F11 KLKB1 PLG SKIL SMURF2
Entrez ID		3818	7980
HPRD ID		01971	08962
Ensembl ID		ENSG00000164344	ENSG00000105825
Uniprot IDs		A8K9A9 B4DMX2 E9PBC5 P03952	P48307
PDB IDs		2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P	1ZR0
Enriched GO Terms of Interacting Partners?
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