ITGB3 and ILK

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ITGB3	ILK
Description		integrin subunit beta 3	integrin linked kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Sarcomere Lamellipodium
	Molecular Function	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Migration Protein Phosphopantetheinylation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Regulation Of Protein Localization Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Platelet Aggregation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Low-density Lipoprotein Receptor Activity	Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs		Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Levothyroxine Tirofiban Resveratrol Lefradafiban LM-609 Fradafiban Ferric maltol
Diseases		Glanzmann thrombasthenia Allograft rejection
GWAS		Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) High chromosomal aberration frequency (chromosome type) ( 31586183) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Malaria ( 31844061)
Interacting Genes		49 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN	42 interacting genes: AKT1 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		3690	3611
HPRD ID		01428	03842
Ensembl ID		ENSG00000259207	ENSG00000166333
Uniprot IDs		P05106	Q13418 V9HWF0
PDB IDs		1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU 6NAJ 6V4P	2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?
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