IL1RN and COPS3

Data Source:
BioGRID (biochemical, far western blotting)

		IL1RN	COPS3
Description		interleukin 1 receptor antagonist	COP9 signalosome subunit 3
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity	Protein Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Interleukin-1-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition In Utero Embryonic Development Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Post-translational Protein Modification
Pathways		Interleukin-10 signaling Interleukin-1 signaling	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs		Rilonacept
Diseases		Graft-versus-host disease
GWAS		Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP	32 interacting genes: ARAF ARF4 C17orf75 CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53
Entrez ID		3557	8533
HPRD ID		00978	07262
Ensembl ID		ENSG00000136689	ENSG00000141030
Uniprot IDs		A0A024R528 P18510	B4DN01 Q9UNS2
PDB IDs		1ILR 1ILT 1IRA 1IRP 1ITN 2IRT	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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