IL1RN

Description		interleukin 1 receptor antagonist
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Interleukin-1-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-1 signaling
Drugs		Rilonacept
Diseases		Graft-versus-host disease
GWAS		Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		3557
HPRD ID		00978
Ensembl ID		ENSG00000136689
Uniprot IDs		A0A024R528 P18510
PDB IDs		1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?
Tagcloud ?