IFNGR2 and ENTPD3

Data Source:
BioGRID (two hybrid)

		IFNGR2	ENTPD3
Description		interferon gamma receptor 2	ectonucleoside triphosphate diphosphohydrolase 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding	Guanosine-diphosphatase Activity Protein Binding ATP Binding Nucleoside-diphosphatase Activity Nucleoside-triphosphatase Activity Uridine-diphosphatase Activity DATP Phosphohydrolase Activity DCTP Phosphohydrolase Activity DUTP Phosphohydrolase Activity DTTP Phosphohydrolase Activity GTP Phosphohydrolase Activity 8-oxo-dGTP Phosphohydrolase Activity DGTP Phosphohydrolase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway	Nucleoside Diphosphate Catabolic Process Nucleoside Triphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS	Phosphate bond hydrolysis by NTPDase proteins
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)	Eosinophil percentage of white cells ( 32888494) Neuroticism ( 29255261)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24	16 interacting genes: ARL13B CREB3L1 ERGIC3 FAM209A FNDC9 GGT6 GPA33 IFNGR2 LEUTX LHFPL5 LMNA MUC1 PTPN5 STX2 SYNE4 TMEM106A
Entrez ID		3460	956
HPRD ID		00956	16014
Ensembl ID		ENSG00000159128	ENSG00000168032
Uniprot IDs		A8K881 E7EUY1 P38484	O75355
PDB IDs		5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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