IFNGR2 and CD302

Data Source:
BioGRID (two hybrid)

		IFNGR2	CD302
Description		interferon gamma receptor 2	CD302 molecule
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Microvillus Cell Cortex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Filopodium
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding	Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway	Phagocytosis
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)	Metabolite levels ( 23823483) Tourette syndrome ( 30818990)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24	8 interacting genes: ARL13B CD53 ERGIC3 FATE1 GET1 GPX8 IFNGR2 OPRM1
Entrez ID		3460	9936
HPRD ID		00956	09906
Ensembl ID		ENSG00000159128	ENSG00000241399
Uniprot IDs		A8K881 E7EUY1 P38484	A0A087WT00 Q8IX05
PDB IDs		5EH1 6E3K 6E3L	2NAN
Enriched GO Terms of Interacting Partners?
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