IFNAR1 and STAT2

Data Source:
HPRD (in vitro, in vivo)

		IFNAR1	STAT2
Description		interferon alpha and beta receptor subunit 1	signal transducer and activator of transcription 2
Image
GO Annotations	Cellular Component	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Chromatin Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway	Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Viral Process Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Mitochondrial Fission
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)	Axial length ( 24144296) Height ( 20881960 25429064 23456168) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		3454	6773
HPRD ID		00126	02778
Ensembl ID		ENSG00000142166	ENSG00000170581
Uniprot IDs		A0A494C0E2 P17181	P52630 R9QE65
PDB IDs		3S98 3SE3 3SE4 4PO6	2KA4 6UX2 6WCZ
Enriched GO Terms of Interacting Partners?
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