IFNAR1 and IFNA2

Data Source:
HPRD (in vivo)

		IFNAR1	IFNA2
Description		interferon alpha and beta receptor subunit 1	interferon alpha 2
Image
GO Annotations	Cellular Component	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding	Cytokine Activity Type I Interferon Receptor Binding Protein Binding
	Biological Process	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta	Sifalimumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)	Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		25 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	3 interacting genes: IFNAR1 IFNAR2 TIMMDC1
Entrez ID		3454	3440
HPRD ID		00126	00950
Ensembl ID		ENSG00000142166	ENSG00000188379
Uniprot IDs		A0A494C0E2 P17181	P01563
PDB IDs		3S98 3SE3 3SE4 4PO6	1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?
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