IFNAR1 and IFNAR2

Data Source:
BioGRID (imaging technique, affinity chromatography technology)
HPRD (in vitro)

		IFNAR1	IFNAR2
Description		interferon alpha and beta receptor subunit 1	interferon alpha and beta receptor subunit 2
Image
GO Annotations	Cellular Component	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		25 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	14 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		3454	3455
HPRD ID		00126	03850
Ensembl ID		ENSG00000142166	ENSG00000159110
Uniprot IDs		A0A494C0E2 P17181	P48551 Q9BUA0
PDB IDs		3S98 3SE3 3SE4 4PO6	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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