ID3 and CNOT3

Data Source:
BioGRID (two hybrid)

		ID3	CNOT3
Description		inhibitor of DNA binding 3, HLH protein	CCR4-NOT transcription complex subunit 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity Transcription Regulator Activity Transcription Regulator Inhibitor Activity Leptomycin B Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA Replication Multicellular Organism Development Central Nervous System Development Heart Development Muscle Organ Development Response To Wounding Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Epithelial Cell Differentiation Notochord Development Circadian Regulation Of Gene Expression Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Cellular Response To Leptomycin B	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Silencing By RNA Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance
Pathways		NGF-stimulated transcription	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		49 interacting genes: ADD1 ANKS1A ATF3 BOLA2 BOLA2B C22orf39 CBFA2T2 CDK2 CNOT3 CREB5 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 FRS3 GATA4 GNB2 GTF2A1L GUCD1 HES1 HOXA1 ID4 IFI16 IKBKG KAT5 KRTAP26-1 LMO4 MLX MSGN1 MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SDCBP SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626	8 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3
Entrez ID		3399	4849
HPRD ID		02608	05368
Ensembl ID		ENSG00000117318	ENSG00000088038
Uniprot IDs		Q02535	A0A024R4R3 O75175
PDB IDs		2LFH	4C0D 4C0G 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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