CNOT3 and CNOT8

Data Source:
HPRD (in vivo, two hybrid)

		CNOT3	CNOT8
Description		CCR4-NOT transcription complex subunit 3	CCR4-NOT transcription complex subunit 8
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Silencing By RNA Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)	High light scatter reticulocyte count ( 32888494)
Interacting Genes		8 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3	9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2
Entrez ID		4849	9337
HPRD ID		05368	07225
Ensembl ID		ENSG00000088038	ENSG00000155508
Uniprot IDs		A0A024R4R3 O75175	B7Z9U0 Q9UFF9
PDB IDs		4C0D 4C0G 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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