HOXA3 and ARPC3

Data Source:
BioGRID (two hybrid, two hybrid)

		HOXA3	ARPC3
Description		homeobox A3	actin related protein 2/3 complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding HMG Box Domain Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Angiogenesis Blood Vessel Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Cartilage Development Parathyroid Gland Development Positive Regulation Of Receptor Binding	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Lymphocyte counts ( 32888494) Mean arterial pressure ( 27618448) Monocyte count ( 32888494 27863252) Pulse pressure ( 30487518) Systolic blood pressure ( 28135244 27618448 30487518) White blood cell count ( 32888494)	Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		10 interacting genes: ALX4 ARPC3 POT1 PWP1 RCHY1 SEC23B SOX10 TERF1 TINF2 ZDHHC17	30 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		3200	10094
HPRD ID		00842	09175
Ensembl ID		ENSG00000105997	ENSG00000111229
Uniprot IDs		A0A024RA33 A4D182 B3KPN8 O43365	O15145
PDB IDs			6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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