ARPC3 and THNSL2

Data Source:
HPRD (two hybrid)

		ARPC3	THNSL2
Description		actin related protein 2/3 complex subunit 3	threonine synthase like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome	Cellular_component Extracellular Space
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Molecular_function Threonine Synthase Activity Cytokine Activity Pyridoxal Phosphate Binding Serine Binding
	Biological Process	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus	Signal Transduction Biological_process Serine Family Amino Acid Catabolic Process Dephosphorylation 2-oxobutyrate Biosynthetic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)	Blond vs. brown/black hair color ( 30531825) Non-melanoma skin cancer ( 29739929) Plasma clusterin levels ( 26545630) Visceral fat ( 22589738)
Interacting Genes		30 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576	2 interacting genes: ARPC3 ZBTB16
Entrez ID		10094	55258
HPRD ID		09175	07715
Ensembl ID		ENSG00000111229	ENSG00000144115
Uniprot IDs		O15145	A8K0C1 Q86YJ6
PDB IDs		6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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