HMGB2 and PKNOX1

Data Source:
BioGRID (two hybrid)

		HMGB2	PKNOX1
Description		high mobility group box 2	PBX/knotted 1 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Apoptosis induced DNA fragmentation	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS			Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		38 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 TSNAX ZNF428 ZNF622 ZNF668	23 interacting genes: APP BLOC1S5 BORCS6 FAM110B FHL2 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 MPP3 NUP58 PAX6 PBX1 PBX2 PBX4 POU2F1 RFX3 TET2 TLX1 VPS37C ZBTB3
Entrez ID		3148	5316
HPRD ID		01229	03653
Ensembl ID		ENSG00000164104	ENSG00000160199
Uniprot IDs		P26583	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs			1X2N
Enriched GO Terms of Interacting Partners?
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