HMGB2 and HACD3

Data Source:
BioGRID (two hybrid)

		HMGB2	HACD3
Description		high mobility group box 2	3-hydroxyacyl-CoA dehydratase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Focal Adhesion Integral Component Of Endoplasmic Reticulum Membrane Nuclear Membrane
	Molecular Function	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding	GTPase Activator Activity Protein Binding 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Very-long-chain 3-hydroxyacyl-CoA Dehydratase Activity 3-hydroxy-arachidoyl-CoA Dehydratase Activity 3-hydroxy-behenoyl-CoA Dehydratase Activity 3-hydroxy-lignoceroyl-CoA Dehydratase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	I-kappaB Kinase/NF-kappaB Signaling Activation Of JUN Kinase Activity Small GTPase Mediated Signal Transduction Rac Protein Signal Transduction Sphingolipid Biosynthetic Process Fatty Acid Elongation Very Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of GTPase Activity Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Pathways		Apoptosis induced DNA fragmentation	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS			Hemoglobin levels ( 32327693)
Interacting Genes		38 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 TSNAX ZNF428 ZNF622 ZNF668	3 interacting genes: HMGB2 NEAT1 RAC1
Entrez ID		3148	51495
HPRD ID		01229	11037
Ensembl ID		ENSG00000164104	ENSG00000074696
Uniprot IDs		P26583	H3BRL8 Q9P035
PDB IDs
Enriched GO Terms of Interacting Partners?
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