HMBS and RANBP9

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		HMBS	RANBP9
Description		hydroxymethylbilane synthase	RAN binding protein 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Nuclear Body
	Molecular Function	Hydroxymethylbilane Synthase Activity Protein Binding	Protein Binding Enzyme Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Peptidyl-pyrromethane Cofactor Linkage	MAPK Cascade Cytoskeleton Organization Microtubule Nucleation Cell Surface Receptor Signaling Pathway Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Heme biosynthesis	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
Drugs
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Apolipoprotein A1 levels ( 32203549)	Breast cancer ( 29059683 23535729)
Interacting Genes		4 interacting genes: APP PICK1 RANBP9 ZDHHC17	56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5
Entrez ID		3145	10048
HPRD ID		01440	04835
Ensembl ID		ENSG00000256269	ENSG00000010017
Uniprot IDs		P08397	A0A024QZW3 Q96S59
PDB IDs		3ECR 3EQ1 5M6R 5M7F	5JI7 5JI9 5JIU
Enriched GO Terms of Interacting Partners?
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