HLA-DPB1 and LZTS2

Data Source:
BioGRID (two hybrid)

		HLA-DPB1	LZTS2
Description		major histocompatibility complex, class II, DP beta 1	leucine zipper tumor suppressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Centrosome Cytosol Microtubule Plasma Membrane Midbody Vesicle
	Molecular Function	Protein Binding Peptide Antigen Binding	Protein Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway	Mitotic Cytokinesis Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases		Dilated cardiomyopathy (DCM)
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Anti-rubella virus IgG levels ( 30053915) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Chronic hepatitis B infection ( 24940741 25802187) Dermatomyositis ( 27153935) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Extranodal natural killer T-cell lymphoma (nasal type) ( 27470079) Gait speed in old age ( 28077804) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) IgA nephropathy ( 25305756) Monocyte count ( 27863252) Myositis ( 26291516) Nephropathy ( 21399633) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Plantar warts ( 28928442) Primary biliary cholangitis ( 28425483) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 31243853 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) SjÃ¶gren's syndrome ( 24097066 28076899) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systemic sclerosis ( 21779181) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		8 interacting genes: CD74 COPB1 HLA-DPA1 LZTS2 MEOX2 ROBO2 RTN4 TRIP6	217 interacting genes: ABI2 ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C1orf109 C2CD6 C8orf33 CABP5 CARD9 CATSPER1 CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CSNK1D CWF19L2 DCUN1D1 DGCR6 DGCR6L DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM214B FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648
Entrez ID		3115	84445
HPRD ID		00832	14341
Ensembl ID		ENSG00000223865	ENSG00000107816
Uniprot IDs		I4EC15 P04440	B4DP66 Q9BRK4
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M
Enriched GO Terms of Interacting Partners?
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