HLA-DPB1

Description		major histocompatibility complex, class II, DP beta 1
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases		Dilated cardiomyopathy (DCM)
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Anti-rubella virus IgG levels ( 30053915) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Chronic hepatitis B infection ( 24940741 25802187) Dermatomyositis ( 27153935) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Extranodal natural killer T-cell lymphoma (nasal type) ( 27470079) Gait speed in old age ( 28077804) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) IgA nephropathy ( 25305756) Monocyte count ( 27863252) Myositis ( 26291516) Nephropathy ( 21399633) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Plantar warts ( 28928442) Primary biliary cholangitis ( 28425483) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 31243853 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) SjÃ¶gren's syndrome ( 24097066 28076899) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systemic sclerosis ( 21779181) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Novel Interacting Genes		1 novel interacting genes: HLA-DQA1
Interacting Genes		8 interacting genes: CD74 COPB1 HLA-DPA1 LZTS2 MEOX2 ROBO2 RTN4 TRIP6
Entrez ID		3115
HPRD ID		00832
Ensembl ID		ENSG00000223865
Uniprot IDs		I4EC15 P04440
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M
Enriched GO Terms of Interacting Partners?
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