TRAF7 and CYLD

Data Source:
HPRD (in vivo)

		TRAF7	CYLD
Description		TNF receptor associated factor 7	CYLD lysine 63 deubiquitinase
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleolus Plasma Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding
	Biological Process	Ribosomal Large Subunit Assembly Activation Of MAPKKK Activity Apoptotic Process Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of JNK Cascade Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases			Familial cylindromatosis Multiple familial trichoepithelioma Brooke-Spiegler syndrome
GWAS		Diastolic blood pressure ( 30578418) Height ( 28552196) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420)
Interacting Genes		12 interacting genes: CDC42 CYLD MAP3K3 OGT RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6	23 interacting genes: AKT1 AURKB DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 PLK4 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2D2 UBE2S
Entrez ID		84231	1540
HPRD ID		06977	05427
Ensembl ID		ENSG00000131653	ENSG00000083799
Uniprot IDs		B3KQY7 Q6Q0C0	A0A024R6T1 Q9NQC7
PDB IDs			1IXD 1WHL 1WHM 2VHF
Enriched GO Terms of Interacting Partners?
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