HGFAC and KLKB1

Data Source:
HPRD (in vitro)

		HGFAC	KLKB1
Description		HGF activator	kallikrein B1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Cytosol	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Proteolysis Blood Coagulation Zymogen Activation	Factor XII Activation Proteolysis Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways		MET Receptor Activation	Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs			Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases			Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 27989323 25998175) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)	Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite levels ( 24625756 23093944)
Interacting Genes		10 interacting genes: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1	8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		3083	3818
HPRD ID		05184	01971
Ensembl ID		ENSG00000109758	ENSG00000164344
Uniprot IDs		D6RAR4 Q04756	A8K9A9 B4DMX2 E9PBC5 P03952
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U	2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P
Enriched GO Terms of Interacting Partners?
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