HGFAC and SPINT2

Data Source:
HPRD (in vitro, in vivo)

		HGFAC	SPINT2
Description		HGF activator	serine peptidase inhibitor, Kunitz type 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Cytosol	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Blood Coagulation Zymogen Activation	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		MET Receptor Activation	MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 27989323 25998175) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)	Blood protein levels ( 30072576 29875488) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494)
Interacting Genes		10 interacting genes: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1	6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4
Entrez ID		3083	10653
HPRD ID		05184	05495
Ensembl ID		ENSG00000109758	ENSG00000167642
Uniprot IDs		D6RAR4 Q04756	A0A140VJV6 O43291
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U	4U32
Enriched GO Terms of Interacting Partners?
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