RPA4 and MUTYH

Data Source:
HPRD (in vitro, in vivo)

		RPA4	MUTYH
Description		replication protein A4	mutY DNA glycosylase
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Single-stranded DNA Binding Protein Binding	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation Nucleotide-excision Repair Nuclear DNA Replication	DNA Repair Base-excision Repair Mismatch Repair Depurination
Pathways		Activation of the pre-replicative complex
Drugs
Diseases			Familial adenomatous polyposis
GWAS			Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		8 interacting genes: APP MSH2 MSH3 MUTYH PTRHD1 RPA1 RPA3 XPA	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		29935	4595
HPRD ID		06591	05380
Ensembl ID		ENSG00000204086	ENSG00000132781
Uniprot IDs		Q13156	D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7
PDB IDs			1X51 3N5N
Enriched GO Terms of Interacting Partners?
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