GRM8 and GPRASP1

Data Source:
HPRD (in vitro)

		GRM8	GPRASP1
Description		glutamate metabotropic receptor 8	G protein-coupled receptor associated sorting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytosol
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Glutamic acid
Diseases
GWAS		Anti-saccade response ( 29064472 25387707) Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Creutzfeldt-Jakob disease (sporadic) ( 25918841) Depression (quantitative trait) ( 20800221) Experiencing mood swings ( 29500382) Fasting glucose change (long-term) ( 31263163) Feeling hurt ( 29500382) Feeling worry ( 29500382) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Neurociticism ( 29500382) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Smoking initiation ( 30617275) Type 2 diabetes ( 32499647) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2	47 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1
Entrez ID		2918	9737
HPRD ID		03071	02333
Ensembl ID		ENSG00000179603	ENSG00000198932
Uniprot IDs		O00222	Q5JY77
PDB IDs		6BSZ 6BT5 6E5V
Enriched GO Terms of Interacting Partners?
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