GRM8 and DNAJC5

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GRM8	DNAJC5
Description		glutamate metabotropic receptor 8	DnaJ heat shock protein family (Hsp40) member C5
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Mitochondrion Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Anchored Component Of Membrane Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity	Protein Binding ATP-dependent Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic	Exocytosis Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Chaperone-mediated Protein Folding Regulation Of Synaptic Vesicle Cycle
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs		Glutamic acid
Diseases
GWAS		Anti-saccade response ( 29064472 25387707) Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Creutzfeldt-Jakob disease (sporadic) ( 25918841) Depression (quantitative trait) ( 20800221) Experiencing mood swings ( 29500382) Fasting glucose change (long-term) ( 31263163) Feeling hurt ( 29500382) Feeling worry ( 29500382) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Neurociticism ( 29500382) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Smoking initiation ( 30617275) Type 2 diabetes ( 32499647) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2	56 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CASK CD2 CFTR CGB5 CLCN3 EFNB1 ERC1 FAS FCHO1 GRM8 HBA2 HGS KHDC4 LIN7A LIN7C NECAP1 NRXN3 NUMB PPFIA1 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP1 SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 STX7 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		2918	80331
HPRD ID		03071	08539
Ensembl ID		ENSG00000179603	ENSG00000101152
Uniprot IDs		O00222	Q6AHX3 Q9H3Z4
PDB IDs		6BSZ 6BT5 6E5V	2N04 2N05
Enriched GO Terms of Interacting Partners?
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