GRM2 and SAR1A

Data Source:
BioGRID (two hybrid)

		GRM2	SAR1A
Description		glutamate metabotropic receptor 2	secretion associated Ras related GTPase 1A
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Presynaptic Membrane Astrocyte Projection Integral Component Of Postsynaptic Membrane	Golgi Membrane COPII Vesicle Coat Endoplasmic Reticulum Exit Site
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis	Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Membrane Organization Positive Regulation Of Protein Exit From Endoplasmic Reticulum COPII-coated Vesicle Cargo Loading
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		LY2140023
Diseases
GWAS
Interacting Genes		29 interacting genes: ACBD5 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MFSD14B MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 STOM TAMALIN TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	69 interacting genes: ADGRE2 AIG1 ALG8 APP AQP1 AQP10 AQP3 ASGR1 ATXN1 BCL2L2 C14orf180 C3orf52 CD53 CD81 CES1 CLDN19 CLDND2 CLEC7A CMTM5 COL4A5 CTSA CXCL16 EMP3 ERG28 FAM3C GJB2 GOLT1B GRM2 GYPA HMOX2 JAGN1 LAT LHFPL5 MARCHF5 MIP MOSPD3 NAT8 NRM ORMDL1 PLLP PLN PLP2 RHOT2 RMDN2 SEC22A SERP1 SLC35A1 SMIM1 SNAP47 STX7 STX8 TMEM107 TMEM109 TMEM187 TMEM218 TMEM243 TMEM254 TMEM267 TMEM42 TMEM97 TRAF3 TRAM1L1 TTPA UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5
Entrez ID		2912	56681
HPRD ID		04977	07608
Ensembl ID		ENSG00000164082	ENSG00000079332
Uniprot IDs		Q14416	Q5SQT9 Q9NR31
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ	2GAO
Enriched GO Terms of Interacting Partners?
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