GRM2 and TMEM130

Data Source:
BioGRID (two hybrid)

		GRM2	TMEM130
Description		glutamate metabotropic receptor 2	transmembrane protein 130
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Presynaptic Membrane Astrocyte Projection Integral Component Of Postsynaptic Membrane	Golgi Membrane Golgi Apparatus Integral Component Of Plasma Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		LY2140023
Diseases
GWAS			Decreased low contrast letter acuity in multiple sclerosis ( 31289819)
Interacting Genes		29 interacting genes: ACBD5 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MFSD14B MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 STOM TAMALIN TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	10 interacting genes: GRM2 MFSD5 NKG7 OLFM4 PIGF SLC2A5 SLC35B4 TMEM100 TSPAN2 YIPF6
Entrez ID		2912	222865
HPRD ID		04977	13226
Ensembl ID		ENSG00000164082	ENSG00000166448
Uniprot IDs		Q14416	Q8N3G9
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
Enriched GO Terms of Interacting Partners?
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