BRD7 and H2AC16

Data Source:
HPRD (in vitro)

		BRD7	H2AC16
Description		bromodomain containing 7	H2A clustered histone 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Lysine-acetylated Histone Binding	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Cycle Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Silencing Biological_process
Pathways		Regulation of TP53 Activity through Acetylation	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4-16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PARP1 PCBD1 PLEKHF2 PSMD11 PTPN13 RIF1 RPLP1 SERPINB9 TRIM24	5 interacting genes: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		29117	8332
HPRD ID		12531	09103
Ensembl ID		ENSG00000166164	ENSG00000276903
Uniprot IDs		Q9NPI1	A4FTV9 P0C0S8
PDB IDs		2I7K 5MQ1 6PPA 6V0Q 6V16 6V17 6V1E 6V1F 6V1H	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7JO9 7JOA
Enriched GO Terms of Interacting Partners?
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