BRD7 and BRD3

Data Source:
HPRD (two hybrid)

		BRD7	BRD3
Description		bromodomain containing 7	bromodomain containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Lysine-acetylated Histone Binding	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Cycle Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)	Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Central corneal thickness ( 31798171 29760442) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998 30591961) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 22139419 32888494) Platelet distribution width ( 27863252) Red cell distribution width ( 32888494 27863252 28957414) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4-16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PARP1 PCBD1 PLEKHF2 PSMD11 PTPN13 RIF1 RPLP1 SERPINB9 TRIM24	7 interacting genes: APP BRD7 KPNA3 MAP1LC3B MYC SPOP SPP1
Entrez ID		29117	8019
HPRD ID		12531	03327
Ensembl ID		ENSG00000166164	ENSG00000169925
Uniprot IDs		Q9NPI1	A0A024R8H6 B4DS09 Q15059
PDB IDs		2I7K 5MQ1 6PPA 6V0Q 6V16 6V17 6V1E 6V1F 6V1H	2E7N 2NXB 2OO1 2YW5 3S91 3S92 5A7C 5HFR 5HJC 6BGG 6BGH 6I41 6I5P 6I68 6I7A 6QJU 6U4A 6ULP
Enriched GO Terms of Interacting Partners?
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