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BRD7 and H3C14
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, unspecified method)
BRD7
H3C14
Description
bromodomain containing 7
H3 clustered histone 14
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Histone Binding
Lysine-acetylated Histone Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Negative Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Positive Regulation Of Histone Acetylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
RDNA Heterochromatin Assembly
Chromatin Organization
Nucleosome Assembly
Blood Coagulation
Interleukin-7-mediated Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Pathways
Regulation of TP53 Activity through Acetylation
Interleukin-7 signaling
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Allergic sensitization (
30013184
)
Epilepsy (
30531953
)
Liver enzyme levels (alanine transaminase) (
24124411
)
Medication use (thyroid preparations) (
31015401
)
Interacting Genes
30 interacting genes:
AGR2
BARD1
BHLHE40
BRD3
BTBD2
DVL1
FTH1
H2AC16
H2BC21
H3-3A
H3-4
H3C14
H4-16
HAP1
HNRNPUL1
IRF2
LAMA4
LRIF1
MX1
NEFL
PAFAH1B3
PARP1
PCBD1
PLEKHF2
PSMD11
PTPN13
RIF1
RPLP1
SERPINB9
TRIM24
60 interacting genes:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFL2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
NAP1L4
NASP
NCOA6
NRDC
NSD2
PHF21A
PIM1
PKN1
PRMT6
PTMA
PWWP3A
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
Entrez ID
29117
126961
HPRD ID
12531
11822
Ensembl ID
ENSG00000166164
ENSG00000203811
Uniprot IDs
Q9NPI1
Q71DI3
PDB IDs
2I7K
5MQ1
6PPA
6V0Q
6V16
6V17
6V1E
6V1F
6V1H
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
4MZF
4MZG
4MZH
4OUC
5B0Y
5B0Z
5B40
5BO0
5CIU
5VAC
6ACE
6FML
6T79
6T7A
6T7B
6T7C
6T7D
6X59
6X5A
6XJD
6Y5D
6Y5E
7BQZ
7BU9
7JO9
7JOA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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