BZW2 and EIF2B1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		BZW2	EIF2B1
Description		basic leucine zipper and W2 domains 2	eukaryotic translation initiation factor 2B subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Protein Binding Cadherin Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Nervous System Development Cell Differentiation	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways			Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CDC42 EIF2A EIF2B1 EIF3A GSK3B LINC01554	21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I
Entrez ID		28969	1967
HPRD ID		16571	09458
Ensembl ID		ENSG00000136261	ENSG00000111361
Uniprot IDs		A0A024RA42 Q9Y6E2	Q14232
PDB IDs			3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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