P4HA3 and ACOT8

Data Source:
BioGRID (two hybrid)

		P4HA3	ACOT8
Description		prolyl 4-hydroxylase subunit alpha 3	acyl-CoA thioesterase 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Peroxisomal Matrix Cytosol
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding CoA Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Glutaryl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Acyl-CoA Hydrolase Activity Long-chain Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Protein Targeting To Peroxisome Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Fatty Acid Catabolic Process Viral Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Negative Regulation Of CD4 Production
Pathways		Collagen biosynthesis and modifying enzymes	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		Hippocampal atrophy ( 25625606)
Interacting Genes		50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A	5 interacting genes: FBXO7 P4HA3 PEX5 PRDM16 REL
Entrez ID		283208	10005
HPRD ID		16413	06998
Ensembl ID		ENSG00000149380	ENSG00000101473
Uniprot IDs		Q7Z4N8	A0A494C0N6 O14734
PDB IDs
Enriched GO Terms of Interacting Partners?
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