ETV1 and CCND3

Data Source:
BioGRID (two hybrid)

		ETV1	CCND3
Description		ETS variant transcription factor 1	cyclin D3
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GO Annotations	Cellular Component	Chromatin Nucleus	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Ewing's sarcoma Prostate cancer
GWAS		Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Height ( 28552196 31217584) Intraocular pressure ( 30591961) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Renal underexcretion gout ( 32238385) Type 2 diabetes ( 24509480 32499647 30718926) Verbal declarative memory ( 25648963) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean corpuscular hemoglobin concentration ( 32888494 28017375) Mean corpuscular volume ( 23263863 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ATR CCND3 EP300 ERG JUN KAT2B KCNA2 MAPK14 MAPK3 MAPK8 MAPKAPK2 NCOA2 NCOA3 NSMCE2 PRKACA RPS6KA1 RPS6KA5 SPI1 UBE2I	56 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 VDR
Entrez ID		2115	896
HPRD ID		02765	00452
Ensembl ID		ENSG00000006468	ENSG00000112576
Uniprot IDs		B5MCT2 B7Z2C9 P50549	B3KP19 D6RI00 P30281 Q5T8J1
PDB IDs		4AVP 4BNC 5ILS	3G33
Enriched GO Terms of Interacting Partners?
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