ANK1 and FXYD3

Data Source:
BioGRID (two hybrid)

		ANK1	FXYD3
Description		ankyrin 1	FXYD domain containing ion transport regulator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band Sarcolemma Neuron Projection Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Ion Channel Binding ATPase Binding	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane	Potassium Ion Transport Sodium Ion Transport Chloride Transport Ion Transmembrane Transport Chloride Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases		Hereditary spherocytosis (SPH)
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 24647736 20858683 31213470 28898252) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Insulin levels adjusted for BMI ( 24699409) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252 28017375) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 32499647 30718926 28869590 22456796)
Interacting Genes		28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN	64 interacting genes: AGR3 ANK1 AQP6 AQP9 BCL2L13 BEST2 CD79A CNR2 CREB3 CREB3L1 CYB5R3 EBP ERG28 ERGIC3 FAM209A FBXL12 FCGR2A FFAR2 GHITM GPR152 GPR37L1 GPR42 GPRC5D IBSP KASH5 KCNN4 LMNA LTC4S MAPK6 MFSD11 MFSD5 MGST1 MTIF3 NR4A1 NUDT3 PLPP6 SCN3B SERBP1 SGPL1 SLC10A1 SLC10A6 SLC16A12 SLC18A1 SLC1A1 SLC30A2 SLC35A1 SLC35B1 SLC35C2 SLC39A2 SPNS3 STRIT1 STX3 TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM179B TMEM50B TMEM52B TMEM80 TMEM86A TMEM97 TSPO2 XKR3
Entrez ID		286	5349
HPRD ID		01693	05410
Ensembl ID		ENSG00000029534	ENSG00000089356
Uniprot IDs		B3KX39 P16157	Q14802
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2
Enriched GO Terms of Interacting Partners?
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