ANK1 and SPTB

Data Source:
BioGRID (pull down)

		ANK1	SPTB
Description		ankyrin 1	spectrin beta, erythrocytic
Image
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band Sarcolemma Neuron Projection Postsynaptic Membrane	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein-containing Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Ion Channel Binding ATPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Actin Filament Capping
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases		Hereditary spherocytosis (SPH)	Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 24647736 20858683 31213470 28898252) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Insulin levels adjusted for BMI ( 24699409) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252 28017375) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 32499647 30718926 28869590 22456796)	Daytime sleep phenotypes ( 27126917) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 31049640)
Interacting Genes		28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN	17 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN ENO3 EPB41 MAPT NCAM1 SH2D2A SNAPIN SPTA1 SPTAN1 STAT1 TULP3 YWHAQ
Entrez ID		286	6710
HPRD ID		01693	01686
Ensembl ID		ENSG00000029534	ENSG00000070182
Uniprot IDs		B3KX39 P16157	P11277
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2	1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?
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