SREK1IP1 and MACROH2A1

Data Source:
BioGRID (two hybrid)

		SREK1IP1	MACROH2A1
Description		SREK1 interacting protein 1	macroH2A.1 histone
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding	RDNA Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	MRNA Processing RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Chromatin Silencing Dosage Compensation Regulation Of Lipid Metabolic Process Negative Regulation Of Histone Phosphorylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Gene Expression, Epigenetic Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K27 Methylation Regulation Of Ribosomal DNA Heterochromatin Assembly Establishment Of Protein Localization To Chromatin Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)
Interacting Genes		28 interacting genes: AGPAT3 C4orf45 CCNL1 CT45A1 DDIT4L ELOA2 FGF10 GTF2H4 H2BC15 HPRT1 HSD17B14 LYAR MACROH2A1 NKAPD1 NKAPL NME1 PPCDC PRPF40A PRR13 RBM39 RNF151 RP9 RP9P RPL9 SDCBP SDCBP2 STAC3 THAP1	20 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622
Entrez ID		285672	9555
HPRD ID		08210	13624
Ensembl ID		ENSG00000153006	ENSG00000113648
Uniprot IDs		Q8N9Q2	O75367
PDB IDs			1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC
Enriched GO Terms of Interacting Partners?
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