SREK1IP1 and H2BC15

Data Source:
BioGRID (two hybrid)

		SREK1IP1	H2BC15
Description		SREK1 interacting protein 1	H2B clustered histone 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleosome Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding	DNA Binding Protein Heterodimerization Activity
	Biological Process	MRNA Processing RNA Splicing	Nucleosome Assembly Protein Ubiquitination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)
Interacting Genes		28 interacting genes: AGPAT3 C4orf45 CCNL1 CT45A1 DDIT4L ELOA2 FGF10 GTF2H4 H2BC15 HPRT1 HSD17B14 LYAR MACROH2A1 NKAPD1 NKAPL NME1 PPCDC PRPF40A PRR13 RBM39 RNF151 RP9 RP9P RPL9 SDCBP SDCBP2 STAC3 THAP1	19 interacting genes: BCCIP EWSR1 FAM133A FAM9A H1-7 H2AB2 H2AB3 H2AC18 H2AC19 H2AC4 H2AC8 MACROH2A1 MACROH2A2 NKAPD1 PRR13 RPL22 SPANXN2 SREK1IP1 TSPYL2
Entrez ID		285672	8341
HPRD ID		08210	11899
Ensembl ID		ENSG00000153006	ENSG00000233822
Uniprot IDs		Q8N9Q2	A0A024RCJ9 Q99877
PDB IDs
Enriched GO Terms of Interacting Partners?
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