MACROH2A1 and VCX2

Data Source:
BioGRID (two hybrid)

		MACROH2A1	VCX2
Description		macroH2A.1 histone	variable charge X-linked 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Extracellular Exosome	Cellular_component
	Molecular Function	RDNA Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding	Molecular_function
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Chromatin Silencing Dosage Compensation Regulation Of Lipid Metabolic Process Negative Regulation Of Histone Phosphorylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Gene Expression, Epigenetic Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K27 Methylation Regulation Of Ribosomal DNA Heterochromatin Assembly Establishment Of Protein Localization To Chromatin Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region	Brain Development Biological_process
Pathways
Drugs
Diseases
GWAS
Interacting Genes		20 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622	9 interacting genes: BEND7 DDIT4L GSC2 MACROH2A1 MEOX2 PAX6 STAC3 THAP1 ZNF526
Entrez ID		9555	51480
HPRD ID		13624	06749
Ensembl ID		ENSG00000113648	ENSG00000177504
Uniprot IDs		O75367	Q9H322
PDB IDs		1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC
Enriched GO Terms of Interacting Partners?
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