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POLL and RPA1
Data Source:
HPRD
(in vitro)
POLL
RPA1
Description
DNA polymerase lambda
replication protein A1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Site Of DNA Damage
Molecular Function
DNA Binding
DNA-directed DNA Polymerase Activity
Metal Ion Binding
5'-deoxyribose-5-phosphate Lyase Activity
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Single-stranded Telomeric DNA Binding
Metal Ion Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Base-excision Repair, Gap-filling
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Somatic Hypermutation Of Immunoglobulin Genes
DNA Biosynthetic Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA-dependent DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Meiotic Cell Cycle
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Nonhomologous End-Joining (NHEJ)
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
GWAS
Airway imaging phenotypes (
26030696
)
Bipolar disorder (
31043756
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
40 interacting genes:
APP
CCNDBP1
CDK2
CMTM5
FAM9B
FSD2
GOLGA6L9
HMBOX1
HUWE1
KRT16
KRT19
KRT27
KRT40
KRTAP10-3
KRTAP10-7
LCN2
LDOC1
MAGEA12
MAGEA2
MAGEA2B
MAL2
MCC
MDFI
PCNA
PICK1
PNMA1
PRKD3
REV1
RPA1
SSX2IP
TFCP2
TFIP11
TNFRSF10D
TRIM23
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
ZRANB1
68 interacting genes:
AICDA
AKTIP
ANXA1
ANXA7
ASCC2
ATM
BID
BLM
BRCA2
BRIP1
CCNA1
CCNA2
CCNB1
CDC5L
CPE
CSNK2B
DMC1
EHMT2
ERCC1
ERCC4
EXO5
GNB5
HAX1
HELB
HGH1
HNRNPUL1
HSPA6
HUS1
MCM2
MCM4
MCM6
MCM7
MMS22L
MSH4
MTUS2
MUTYH
ORC2
ORC6
PAXIP1
PCNA
POLL
PRIMPOL
PRKDC
RAD1
RAD23B
RAD51
RAD52
RAD9A
RBM23
RCC1
RECQL
RFWD3
RPA2
RPA3
RPA4
RPS6KA5
SELENBP1
SEM1
SMAD3
TCEA2
TK1
TP53
TREX1
VIM
WRN
XPA
XPC
ZBTB14
Entrez ID
27343
6117
HPRD ID
09394
01565
Ensembl ID
ENSG00000166169
ENSG00000132383
Uniprot IDs
A8K860
B4DE17
Q9UGP5
P27694
PDB IDs
1NZP
1RZT
1XSL
1XSN
1XSP
2BCQ
2BCR
2BCS
2BCU
2BCV
2GWS
2JW5
2PFN
2PFO
2PFP
2PFQ
3C5F
3C5G
3HW8
3HWT
3HX0
3MDA
3MDC
3MGH
3MGI
3PML
3PMN
3PNC
3UPQ
3UQ0
3UQ2
4FO6
4K4G
4K4H
4K4I
4X5V
4XA5
4XQ8
4XRH
4XUS
5CA7
5CB1
5CHG
5CJ7
5CP2
5CR0
5CWR
5DDM
5DDY
5DKW
5III
5IIJ
5IIK
5IIL
5IIM
5IIN
5IIO
5W4G
1EWI
1FGU
1JMC
1L1O
2B29
2B3G
4IJH
4IJL
4IPC
4IPD
4IPG
4IPH
4LUO
4LUV
4LUZ
4LW1
4LWC
4NB3
4O0A
4R4C
4R4I
4R4O
4R4Q
4R4T
5E7N
5EAY
5N85
5N8A
Enriched GO Terms of Interacting Partners
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