POLL and HUWE1

Data Source:
BioGRID (enzymatic study)

		POLL	HUWE1
Description		DNA polymerase lambda	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding 5'-deoxyribose-5-phosphate Lyase Activity	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Somatic Hypermutation Of Immunoglobulin Genes DNA Biosynthetic Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Nonhomologous End-Joining (NHEJ)	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS			Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		40 interacting genes: APP CCNDBP1 CDK2 CMTM5 FAM9B FSD2 GOLGA6L9 HMBOX1 HUWE1 KRT16 KRT19 KRT27 KRT40 KRTAP10-3 KRTAP10-7 LCN2 LDOC1 MAGEA12 MAGEA2 MAGEA2B MAL2 MCC MDFI PCNA PICK1 PNMA1 PRKD3 REV1 RPA1 SSX2IP TFCP2 TFIP11 TNFRSF10D TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H ZRANB1	36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2
Entrez ID		27343	10075
HPRD ID		09394	06608
Ensembl ID		ENSG00000166169	ENSG00000086758
Uniprot IDs		A8K860 B4DE17 Q9UGP5	A0A024R9W5 Q7Z6Z7
PDB IDs		1NZP 1RZT 1XSL 1XSN 1XSP 2BCQ 2BCR 2BCS 2BCU 2BCV 2GWS 2JW5 2PFN 2PFO 2PFP 2PFQ 3C5F 3C5G 3HW8 3HWT 3HX0 3MDA 3MDC 3MGH 3MGI 3PML 3PMN 3PNC 3UPQ 3UQ0 3UQ2 4FO6 4K4G 4K4H 4K4I 4X5V 4XA5 4XQ8 4XRH 4XUS 5CA7 5CB1 5CHG 5CJ7 5CP2 5CR0 5CWR 5DDM 5DDY 5DKW 5III 5IIJ 5IIK 5IIL 5IIM 5IIN 5IIO 5W4G	2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL
Enriched GO Terms of Interacting Partners?
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