HUWE1 and ATOH1

Data Source:
BioGRID (enzymatic study)

		HUWE1	ATOH1
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	atonal bHLH transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Chromatin Nucleus
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromatin DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	Neuron Migration Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Notch Signaling Pathway Axon Guidance Central Nervous System Development Cerebral Cortex Development Neuron Differentiation Inner Ear Morphogenesis Auditory Receptor Cell Fate Specification Auditory Receptor Cell Fate Determination Negative Regulation Of Apoptotic Process Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Colorectal cancer or advanced adenoma ( 30510241) Metabolite levels ( 23823483)
Interacting Genes		36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2	2 interacting genes: HMGB1 HUWE1
Entrez ID		10075	474
HPRD ID		06608	03270
Ensembl ID		ENSG00000086758	ENSG00000172238
Uniprot IDs		A0A024R9W5 Q7Z6Z7	Q92858
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL
Enriched GO Terms of Interacting Partners?
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