HUWE1 and PPP5C

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		HUWE1	PPP5C
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	protein phosphatase 5 catalytic subunit
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex Perikaryon Intracellular Membrane-bounded Organelle Chaperone Complex Proximal Dendrite
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	G-protein Alpha-subunit Binding RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Phosphatase Activity Identical Protein Binding ADP Binding Protein-containing Complex Binding Metal Ion Binding Tau Protein Binding Hsp90 Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	MAPK Cascade Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation DNA Repair Transcription, DNA-templated Protein Dephosphorylation Response To Lead Ion Histone Dephosphorylation Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Peptidyl-serine Dephosphorylation Cellular Response To Hydrogen Peroxide Cellular Response To Cadmium Ion Negative Regulation Of Neuron Death Response To Arachidonic Acid Positive Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling
Drugs			ATP
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Basophil percentage of white cells ( 27863252) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neuroticism ( 29255261) Response to antidepressants in depression ( 29998114) Triglyceride levels ( 32203549)
Interacting Genes		36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2	26 interacting genes: APP CDC16 CDC27 CDC37 CDK20 CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L CSNK1D DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A HUWE1 MAP3K5 MAP3K7 MAPT PPP2R1A PPP2R3A VHL
Entrez ID		10075	5536
HPRD ID		06608	02805
Ensembl ID		ENSG00000086758	ENSG00000011485
Uniprot IDs		A0A024R9W5 Q7Z6Z7	A0A024R0Q7 P53041
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL	1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZVZ 4ZX2 5HPE 5UI1 5WG8
Enriched GO Terms of Interacting Partners?
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