AMPH and SYN1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		AMPH	SYN1
Description		amphiphysin	synapsin I
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Synaptic Vesicle Membrane Leading Edge Membrane	Synaptonemal Complex Golgi Apparatus Cytosol Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Extrinsic Component Of Synaptic Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Phospholipid Binding	Actin Binding Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis Membrane Organization	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Clathrin-mediated endocytosis	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Ankylosing spondylitis ( 30946743) Bitter non-alcoholic beverage consumption ( 31046077) Cerebral microbleeds ( 31209788) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		27 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A ITSN2 KHDRBS1 MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		273	6853
HPRD ID		02687	02433
Ensembl ID		ENSG00000078053	ENSG00000008056
Uniprot IDs		P49418	P17600
PDB IDs		1KY7 1UTC 3SOG 4ATM 5M5S 5M61
Enriched GO Terms of Interacting Partners?
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