AMPH and PPP3CC

Data Source:
BioGRID (two hybrid)

		AMPH	PPP3CC
Description		amphiphysin	protein phosphatase 3 catalytic subunit gamma
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Synaptic Vesicle Membrane Leading Edge Membrane	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Presynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding	Protein Binding Calmodulin Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis Membrane Organization	Protein Dephosphorylation Brain Development Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Clathrin-mediated endocytosis	Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Bitter non-alcoholic beverage consumption ( 31046077) Cerebral microbleeds ( 31209788) Post bronchodilator FEV1 ( 26634245)	General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)
Interacting Genes		27 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A ITSN2 KHDRBS1 MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN	14 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC PPP3R1 SDC2 SPATA33 TGFBR1 THAP7 UNC119
Entrez ID		273	5533
HPRD ID		02687	00236
Ensembl ID		ENSG00000078053	ENSG00000120910
Uniprot IDs		P49418	P48454
PDB IDs		1KY7 1UTC 3SOG 4ATM 5M5S 5M61
Enriched GO Terms of Interacting Partners?
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