AMPH and PLD2

Data Source:
HPRD (in vitro)

		AMPH	PLD2
Description		amphiphysin	phospholipase D2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Synaptic Vesicle Membrane Leading Edge Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse
	Molecular Function	Protein Binding Phospholipid Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis Membrane Organization	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility
Pathways		Clathrin-mediated endocytosis	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis
Drugs			Choline Choline salicylate
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Bitter non-alcoholic beverage consumption ( 31046077) Cerebral microbleeds ( 31209788) Post bronchodilator FEV1 ( 26634245)	Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)
Interacting Genes		27 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A ITSN2 KHDRBS1 MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN	29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL
Entrez ID		273	5338
HPRD ID		02687	03857
Ensembl ID		ENSG00000078053	ENSG00000129219
Uniprot IDs		P49418	O14939
PDB IDs		1KY7 1UTC 3SOG 4ATM 5M5S 5M61	6OHM 6OHO 6OHP 6OHQ 6OHS
Enriched GO Terms of Interacting Partners?
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