GEM and BMP1

Data Source:
BioGRID (two hybrid)

		GEM	BMP1
Description		GTP binding protein overexpressed in skeletal muscle	bone morphogenetic protein 1
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Extracellular Region Extracellular Space Golgi Apparatus Vesicle
	Molecular Function	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation High-density Lipoprotein Particle Assembly Positive Regulation Of Cartilage Development
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BHLHB9 BLOC1S2 BLZF1 BMP1 C1orf131 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 ECSIT EFHC2 EXOSC8 GADD45GIP1 GAS8 GMIP GOLGA2 GOLGA6L9 GOPC HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		2669	649
HPRD ID		11553	00209
Ensembl ID		ENSG00000164949	ENSG00000168487
Uniprot IDs		A0A024R9F5 P55040	P13497
PDB IDs		2CJW 2G3Y 2HT6	3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?
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