BMP1 and COL5A1

Data Source:
HPRD (in vivo)

		BMP1	COL5A1
Description		bone morphogenetic protein 1	collagen type V alpha 1 chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Collagen Type V Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation High-density Lipoprotein Particle Assembly Positive Regulation Of Cartilage Development	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Extracellular Matrix Organization Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs
Diseases			Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Waist-to-hip ratio adjusted for BMI ( 28552196)	Blood pressure ( 24954895) Central corneal thickness ( 32528159 28171582 22814818 31798171 23493294 29760442 30894546 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intraocular pressure ( 29617998) Longevity ( 20834067) Metabolite levels ( 23823483) Phosphatidylcholine levels ( 31551469) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1
Entrez ID		649	1289
HPRD ID		00209	00368
Ensembl ID		ENSG00000168487	ENSG00000130635
Uniprot IDs		P13497	A0A024R8E5 B2ZZ86 P20908 Q59EE7
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	1A89 1A9A
Enriched GO Terms of Interacting Partners?
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