BMP1 and LAMA3

Data Source:
HPRD (in vitro, in vivo)

		BMP1	LAMA3
Description		bone morphogenetic protein 1	laminin subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Basement Membrane Laminin-5 Complex Endoplasmic Reticulum Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation High-density Lipoprotein Particle Assembly Positive Regulation Of Cartilage Development	Morphogenesis Of A Polarized Epithelium Integrin-mediated Signaling Pathway Axon Guidance Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs			Lanoteplase
Diseases			Laryngoonychocutaneous syndrome Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA) Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Waist-to-hip ratio adjusted for BMI ( 28552196)	Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 22959728) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1
Entrez ID		649	3909
HPRD ID		00209	02883
Ensembl ID		ENSG00000168487	ENSG00000053747
Uniprot IDs		P13497	A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?
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