GEM and MGLL

Data Source:
BioGRID (two hybrid)

		GEM	MGLL
Description		GTP binding protein overexpressed in skeletal muscle	monoglyceride lipase
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane
	Molecular Function	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Lysophospholipase Activity Protein Binding Lipase Activity Protein Homodimerization Activity Acylglycerol Lipase Activity
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity	Lipid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Regulation Of Signal Transduction Arachidonic Acid Metabolic Process Triglyceride Catabolic Process Acylglycerol Acyl-chain Remodeling Acylglycerol Catabolic Process Regulation Of Inflammatory Response Regulation Of Sensory Perception Of Pain Monoacylglycerol Catabolic Process Regulation Of Endocannabinoid Signaling Pathway
Pathways			Acyl chain remodeling of DAG and TAG Triglyceride catabolism Arachidonate production from DAG
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Carotid intima media thickness x smoking interaction ( 32117412) Pars triangularis volume ( 31530798) Refractive error ( 32231278)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BHLHB9 BLOC1S2 BLZF1 BMP1 C1orf131 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 ECSIT EFHC2 EXOSC8 GADD45GIP1 GAS8 GMIP GOLGA2 GOLGA6L9 GOPC HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	25 interacting genes: ADRB2 AQP6 CD79A CHGB COQ9 EBAG9 FAM209A FCER1G GEM GOLT1A GPR152 HSD17B13 HTR4 LMNA LTB4R2 MFSD14B MSRB3 PEX12 SDCBP SLC10A6 SLC66A2 SLC7A14 STOM TMEM35A TMX2
Entrez ID		2669	11343
HPRD ID		11553	17574
Ensembl ID		ENSG00000164949	ENSG00000074416
Uniprot IDs		A0A024R9F5 P55040	A0A0C4DFN3 B2ZGL7 E7EWX8 Q99685
PDB IDs		2CJW 2G3Y 2HT6	3HJU 3JW8 3JWE 3PE6 4UUQ 5ZUN 6AX1 6BQ0
Enriched GO Terms of Interacting Partners?
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