GATA4 and MDC1

Data Source:
BioGRID (unspecified method)

		GATA4	MDC1
Description		GATA binding protein 4	mediator of DNA damage checkpoint 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Activating Transcription Factor Binding Sequence-specific DNA Binding NFAT Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Heart Looping Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Wound Healing Response To Drug Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Regulation Of Protein Kinase B Signaling Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Apoptotic Signaling Pathway	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases		Atrial septal defect
GWAS		Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28135244 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728) Triglyceride levels ( 32203549)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		24 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2	40 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		2626	9656
HPRD ID		08994	16252
Ensembl ID		ENSG00000136574	ENSG00000137337
Uniprot IDs		B3KUF4 B6DU75 P43694	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs		2M9W	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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